Nitrate Therapy for Heart Failure
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چکیده
Accreditation and Designation Statement The American College of Cardiology Foundation (ACCF) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The ACCF designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity.
منابع مشابه
An update on nitrate tolerance: can it be avoided?
Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...
متن کاملAn update on nitrate tolerance: can it be avoided?
Organic nitrates have been recognized by physicians as potent vasodilators and effective therapy for angina pectoris for over 100 years."2 Despite the advent of beta-blockers and calcium channel antagonists in the 1960s the organic nitrates remain important antianginal agents and are well-established as the drugs of choice in acute angina. Recently interest in nitrate therapy has increased as a...
متن کاملHeme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress
Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction, and chronic congestive heart failure. A major therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents, and this phenomenon is largely based on inductio...
متن کاملNitrate therapy for heart failure: benefits and strategies to overcome tolerance.
Combination therapy with hydralazine and nitrates can improve outcomes in patients with heart failure and low ejection fraction. However, this combination is underused in clinical practice for several reasons, including side effects related to hydralazine and polypharmacy. Some of the benefits seen with hydralazine, including afterload reduction and attenuation of nitrate tolerance, have also b...
متن کاملRandomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure.
BACKGROUND Reduced cGMP production caused by increased superoxide has been proposed as a mechanism of nitrate tolerance during continuous nitrate therapy. This study was designed to evaluate the effects of ascorbate, an antioxidant, on the development of nitrate tolerance during continuous nitrate therapy in patients with congestive heart failure. METHODS AND RESULTS Twenty patients with cong...
متن کاملImpact of Nitrate Use on Survival in Acute Heart Failure: A Propensity‐Matched Analysis
BACKGROUND There is limited evidence that the use of nitrates in acute decompensated heart failure early after presentation to a hospital can improve clinical outcomes. We aimed to determine whether early nitrate exposure is associated with improved survival in a large retrospective cohort study. METHODS AND RESULTS We examined 11 078 acute decompensated heart failure patients who presented t...
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تاریخ انتشار 2013